In vivo, however, the contribution of Dectin-PGE2-OX40L signaling axis in egg antigen-driven Th2 polarization appears to be much more dominant, given that interference with Syk or Dectin signaling did result in an impaired Th2 response induced by complete SEA or by a natural infection with S. mansoni, respectively. Here, TNFSF4 is linked to infection.