To test the sensitivity of Stat1-/- mice to ZIKV infection, adult Stat1-/- mice were intraperitoneally challenged with 4x103 to 4x106 ZIKV plaque forming units (pfu)/mouse that resulted in significant weight loss and 100% mortality by two weeks at the doses tested (Fig 1A). This evidence concerns the gene STAT1 and Zika virus infectious disease.