STAT1 and Zika virus infectious disease: Because mice are naturally immune to a ZIKV infection, mouse strains defective in antiviral immune pathways such as AG129, Ifnar-/-, Stat1-/-, Stat2-/- and Irf3-/-Irf5-/-Irf7-/- triple knock out mice have been used in ZIKV pathogenesis research [11–15].