To assess whether cancer cell lines and helminth parasites share similar features in shaping human monocyte gene expression, human monocytes were either exposed to CMFDA- labeled cancer cell lines (breast cancer; MDA-MB-231 (MDA), ovarian cancer; OVCAR-3 (OVCAR), and glioblastoma; U87-MG (U87)) or to live mf of Brugia malayi for 48 hours, sorted for CD45+/CMFDA- monocytes and assessed for mRNA expression by RT-PCR. The gene discussed is PTPRC; the disease is cancer.