TSC2 and tuberous sclerosis: The incidence of AML in the general population is estimated to be 0.13%, and it is more prevalent in women than in men.[1,2] AML is often comorbid with tuberous sclerosis complex (TSC), an autosomal dominant disease characterized by benign neoplasms involving multiple systems.[3] The majority of patients with TSC (80%) can develop AML, and TSC is caused by mutations in TSC1 (9q34) or TSC2 (16p13) genes.