CCN2 and neoplasm: For example, it can induce expression of connective tissue growth factor (CTGF) and c‐Myc proteins and therefore promote tumour proliferation of colorectal adenocarcinoma27 and gastric adenocarcinoma.8 Similarly, in oral squamous cell carcinoma, TEAD4 ensures the high levels of cyclins and cyclin‐dependent kinases (CDKs), and subsequently accelerate cell cycle.28 However, in the current study, we did not find any significant effect of TEAD4 on cell proliferation of lung adenocarcinoma (LAD) cells.