Its aberrant overexpression significantly associated with aggressive clinicopathological features and inferior survival.14, 17, 18 Furthermore, SUZ12 knock‐down induced impaired tumour growth, invasion and metastasis in bladder, gastric and lung cancer.17, 19, 20 However, on contrary, recurrent loss‐of‐function somatic alterations of SUZ12 have been identified in malignant peripheral nerve sheath tumour and contribute to its initiation and progression.16 Therefore, these data highlight the complexity of biological roles of SUZ12 underlying tumorigenesis in diverse contexts. The gene discussed is SUZ12; the disease is malignant peripheral nerve sheath tumor.