This is consistent with previous findings which revealed elevated SUZ12 in gastric, bladder, lung and colorectal cancer.14, 18, 19, 35 Moreover, our findings from 4NQO‐induced animal model reveal that increased SUZ12 expression was observed during disease progression from hyperplasia to invasive carcinoma, thus giving further support to the idea that SUZ12 as a bona fide oncogene promotes tumorigenesis in multiple contexts including HNSCC. The gene discussed is SUZ12; the disease is colorectal cancer.