As shown in Figure 1A‐F, data mining and interrogation from Oncomine database indicated significant higher expression of SUZ12 mRNA in HNSCC samples from several independent patient cohorts as compared to normal counterparts, respectively, except the Cromer's cohort.27, 28, 29, 30, 31, 32, 33 Data integration and analyses from TCGA‐HNSCC cohort (502 cases) using cBioPortal platform indicated that total frequency of SUZ12 genetic alterations in HNSCC samples was less than 2.5%. Here, SUZ12 is linked to head and neck squamous cell carcinoma.