SCNN1B and lung disorder: 2015), MΦ possess the capability of sensing and responding to inflammatory triggers in distressed airspaces in pulmonary diseases and, accordingly, influence the inflammatory responses. MΦ responses per se and MΦ‐epithelial interactions, however, are poorly understood, thus in vivo investigations in suitable airway disease models are warranted. One relevant model of human CB, that is, the Scnn1b‐Tg mouse, provides a suitable tool to understand the MΦ‐mediated responses in the muco‐obstructive airspaces.