SCNN1B and bacterial infectious disease: To test these hypotheses, the effects of LysM‐Cre regulated DTA expression on MΦ numbers and function in WT (without Scnn1b transgene) and Scnn1b‐Tg (with Scnn1b transgene) mice, the incidence of bacterial infection in Scnn1b‐Tg mice, and the effects of numerical/functional deficiencies of MΦ populations on airway and alveolar pathology of Scnn1b‐Tg mice were investigated.