AKT2, one of the three isoforms of the protein kinases B (PKB) family highly expressed in breast tumors, is a major downstream effector of the canonical phosphatidylinositol 3-kinase (PI3-K) pathway which appears generally associated with acquisition of a malignant phenotype in cancer cells, and also associated with CSC tumorigenicity (Cheng et al., 2007, 2008; Umemura et al., 2014; Rafael et al., 2015). This evidence concerns the gene AKT2 and cancer.