Previously, Flot1 had been implicated in the internalization and membrane targeting of the dopamine transporter (DAT), which shares a high structural homology with SERT.19 As a result of this similarity, Flot1 was considered an obvious candidate protein for interacting with SERT, with the additional potential of this protein‐protein interaction being relevant in MDD. Here, FLOT1 is linked to major depressive disorder.