Stress exposure is recognized as the major external contributing factor to risk for the development of psychopathologies, with an enhanced sensitivity exhibited during early life but highly relevant throughout adulthood.48, 49, 50 In order to evaluate how environmental challenges impinge on the genetic background of Flot1 deficiency to lead to depression‐like behavior, we subjected Flot1 KO mice and WT littermates to chronic CORT treatment. Here, FLOT1 is linked to depressive symptom measurement.