Traditionally, a combination of transferrin saturation (TSAT) and serum ferritin was used to assess iron status in adults and children with CKD, and these measures are still recommended in The National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (KDOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) anemia guidelines [19, 20]. The gene discussed is TF; the disease is chronic kidney disease.