These newly spliced genes are important for promoting CRPC-NE tumor establishment, where the reprogrammed functions of CRPC-NE-unique MEAF6-1 splice variants can drive PCa cell proliferation, invasion, tumor growth, and, along with the PHF21A constitutive splice variant, may drive a neural program at the epigenomic level. The gene discussed is PHF21A; the disease is neoplasm.