Our lab has recently observed that SRRM4 mRNA is present in small populations of AdPC tumors, where the prevalence and mRNA expression of SRRM4 increases after therapeutic interventions such as ARPI in CRPC-Ad tumors, suggesting that active AR signaling can repress SRRM4 expression, and consequently function (Li et al., manuscript under review). Here, SRRM4 is linked to Alzheimer disease.