Furthermore, the resulting reprogrammed function of the SRRM4-mediated PHF21A splice variant may also attenuate the transcriptional repression of REST and its associated cofactors, LSD1, coREST, and HDAC1/2 on neuronal-specific genes, whereby lifting the REST-dependent histone methylation repression of neuronal differentiation and increasing the likelihood of NE lineage cell differentiation in PCa cells. Here, PHF21A is linked to posterior cortical atrophy.