Although further investigation is needed to fully elucidate the mechanism of FOXA1/2 in the NE differentiation of PCa cells, these findings suggest a contrasting role for FOXA1 and FOXA2 in regulating lineage plasticity where FOXA1 is involved in inhibiting NE-differentiation and promoting the differentiated state of AdPC cells. The gene discussed is FOXA1; the disease is posterior cortical atrophy.