In addition, pravastatin (a member of the drug class of statins) is used for the treatment of dyslipidemia and the prevention of steroid-induced osteonecrosis of the femoral head (ONFH) by activating Wnt signaling pathway, include increasing the expression of LRP5, β-catenin and suppressing the expression of PPARγ (Jiang et al., 2014; Nozaki et al., 2012). This evidence concerns the gene LRP5 and metabolic syndrome.