Meanwhile, SFRP4 c1019G9A polymorphism has been reported to be associated with the bone mineral density (BMD), and the AA genotype had a higher level of serum bone alkaline phosphatase and lower lumbar spine BMD when compared with the GG genotype, suggesting a higher risk for osteoporosis at the lumbar spine was found in patients who carriers of AA genotype (Lee et al., 2010). This evidence concerns the gene SFRP4 and osteoporosis.