AKT1 and hepatitis C virus infection: Importantly, hepatitis C virus activates PI3K-Akt signaling to enhance entry and replication, and meanwhile PI3K-Akt signaling pathway also can increase HCV translation (Liu et al., 2012; Shi, Hoffman & Liu, 2016), which suggest that PI3K-Akt signaling pathway is associated with hepatitis C virus infection specifically.