TP53 and cancer: Among the results of the PoTRA analysis for HCC in Table S2, we can find many pathways involved in HCC in the top 10 significant pathways, such as Cytokine-cytokine receptor interaction, cAMP signaling pathway, p53 signaling pathway, etc. Cytokine-cytokine receptor interaction exerts a vast array of immunoregulatory actions critical to cancers (Schreiber & Walter, 2010; Spangler et al., 2015).