The BV ICP47 protein lacks the TAP-binding domain of the HSV ICP47 and thus BV fails to downregulate MHC expression in both human and macaque cells, suggesting that the differences in BV and HSV evasion of activation of antiviral T cells and susceptibility to NK cells are not responsible for any differential pathogenicity of BV in humans versus macaques [157]. The gene discussed is HLA-C; the disease is bacterial vaginosis.