This leads to the restoration of the three signals required for proper T cell activation, including increased antigen presentation following cancer cell apoptosis and phagocytosis (signal # 1), co-stimulation from matured and recruited APCs (signal # 2), and the production of cytokines from both the cancer (e.g., IFNs) and APCs (e.g., IL-1β) (signal # 3). Here, IL1B is linked to cancer.