The serum antibodies of leprosy patients reacted with tropomyosin alpha striated muscle isoforms (TM) (Homo sapiens) by MALDI analysis, whereas myosin-hyperimmunized rabbit sera that reacted with Mycobacterium leprae soluble antigen (MLSA) was identified as ATP-dependent C1p protease ATP-binding subunit (CLPC) of M. leprae (Table 2). This evidence concerns the gene MYH14 and leprosy.