CXC-chemokine ligand 12 modulates cancer biology principally through two mechanisms: (i) direct/autocrine effects promoting cancer cell growth, metastasis, and angiogenesis; (ii) by indirect/paracrine effects, including recruitment of CXCR4+ cancer cells to CXCL12-expressing organs (BM, liver, thymus, lymph nodes, brain, among others) or CXCR4-expressing stromal cells to tumor sites (69). This evidence concerns the gene CXCR4 and cancer.