Interestingly, using ccr6−/−, ccr7−/−, and cxcr4−/− fetal liver progenitors transduced with oncogenic Notch1-IC, cxcr4 rather than ccr7 was implicated in CNS infiltration by T-ALL cells, in addition to BM engraftment (24). The gene discussed is CCR7; the disease is acute lymphoblastic leukemia.