Differently in B-CLL cells, which also express high levels of surface CXCR4 and where the CXCL12/CXCR4 axis is regarded as a retention signal in tissue niches, CXCR4 has been shown to be a direct NOTCH1 target (13), suggesting a fundamental role of the NOTCH1-CXCR4 axis in the dissemination of B-CLL cells to lymphoid organs. This evidence concerns the gene CXCL12 and B-cell chronic lymphocytic leukemia.