Subsequent experiments to determine how PTEN influences T-ALL homing and survival in the intestine disclosed that reduced PTEN expression (through Pten knockdown) sensitized leukemia cells to CCL25-induced Akt phosphorylation leading to their increased migration in transwell assays, and this effect was largely abrogated following PTEN re-expression (25). Here, PTEN is linked to acute lymphoblastic leukemia.