As the list of genes with highly dynamic regulatory potential are enriched for previously identified putative direct NOTCH1 target genes, it will be interesting to validate CXCR7 as a NOTCH1 direct target as this could add a further layer of complexity to the role played by NOTCH1 in promoting T-ALL retention/dissemination. The gene discussed is ACKR3; the disease is acute lymphoblastic leukemia.