KGD is also known to be present within the CD40 ligand (CD40L) which together with CD40 forms an important dyad relevant for mounting an immune response, autoimmunity, and inflammation; for example, its role has recently been suggested in immunopathology of certain forms of glomerulonephritis (Doublier et al., 2017). The gene discussed is CD40LG; the disease is Autoimmunity.