Besides CagA, several other mechanisms leading to β-catenin activation have been described in H. pylori altering the expression of Wnt ligands (Kirikoshi et al., 2001), activating Wnt receptors (Gnad et al., 2010), suppressing GSK3β (Sokolova et al., 2008; Nakayama et al., 2009), interfering with β-catenin/TCF4 complex by down-regulating the gastric tumor suppressor Runx3 (Liu et al., 2012), and interacting with E-cadherin to disrupt the E-cadherin/β-catenin complex (Murata-Kamiya et al., 2007) highlighting the importance of this signaling pathway in cancer development. Here, CDH1 is linked to cancer.