Wnt pathway, which is crucial for intestinal epithelium homeostasis, is indeed constitutively activated in more than 90% of CRC tumors, and loss of function mutations in its negative regulator APC are found in 80% of non-hypermutated and 50% of hyper-mutated CRC tumors (The Cancer Genome Atlas Network, 2012). This evidence concerns the gene APC and colorectal carcinoma.