Overall, this study demonstrates the existence of a novel axis, p53/miR-30a/ZEB2, that links p53 inactivation to EMT and BC aggressiveness (Fig. 5c), and adds support to the notion that the control of p53 over the various tumoral phenotypes relies on convergent and integrated circuits, in which miRNAs appear as emerging and pivotal nodes. This evidence concerns the gene ZEB2 and breast cancer.