EPAS1 and melanoma: Since in human melanoma cells ascorbic acid could suppress HIF-1α level and activity31, and knockdown of HIF-1α increased TET2 mRNA and protein expression32, as well as HIF-1α could transactivate DNMT3a in leukemia cells33, we examined AA2P’s effects on Hif-1α and Hif-2α in mature oocytes.