We established the tranilast-resistant neurofibroma cells derived from patient 1 that had been exposed to 250 μM tranilast for 20 days, and we found that the abundance of COL3A1 and SOX2 mRNAs was increased in the tranilast-resistant neurofibroma cells (Fig. 8c). This evidence concerns the gene SOX2 and plexiform neurofibroma.