Given that a large proportion ( > 30%) of proteins encoded by hereditary lymphedema-associated genes act on the VEGF-C-VEGFR3 signalling pathway64, our finding that GATA2 regulates VEGF-C responsiveness of LECs may provide an explanation for lymphatic vascular failure caused by GATA2 loss in Emberger syndrome. The gene discussed is FLT4; the disease is lymphedema.