Human heart tissue transcriptome (GSE84796) revealed that the expression of PIK3CG gene was upregulated in the samples from patients with CCC when compared to heart samples from healthy control individuals (Ctl) (relative expression = 5.37; P = 1.0E-5; Student’s t-test with the Benjamini–Hochberg method) or even samples from patients with non-chagasic cardiomyopathy (idiopathic dilated cardiomyopathy, DCM, GSE111544, Relative expression = 6.60; P = 2.1E-8; Student’s t-test with the Benjamini–Hochberg method) (Fig. 9a). The gene discussed is PIK3CG; the disease is idiopathic dilated cardiomyopathy.