Data revealed that the expression of Pik3cg (P = 4.0E-3; unpaired t-test) and Pik3cd (P = 7.4E-6; unpaired t-test) genes, but not Pik3ca, are upregulated in the heart tissue of T. cruzi-infected mice 18 days post infection (dpi) (Fig. 1a). This evidence concerns the gene PIK3CA and infection.