Hence, the results of this study contradict the previous work by Elkhaled et al. 10 but essentially highlight that (i) the methodology for obtaining DWI parameters in tumor plays a crucial role given the spatial heterogeneity and (ii) the ADC might be not the most appropriate parameter to gauge any altered diffusion properties related to the IDH mutation, and DKI should be employed to improve the diagnostic accuracy12. This evidence concerns the gene IDH2 and neoplasm.