After all, the results using the 4 respective selected DKI biomarkers were very competitive in terms of accuracy compared to those using all 54 DKI biomarkers (gliomas grading: 75% vs 78.1%, IDH mutation status: 83.8% vs 83.8%) and higher AUC value (gliomas grading: 0.85 vs 0.79, IDH mutation status: 0.88 vs 0.87), which reflects the effectiveness of the feature selection procedure and also substantially simplifies the application, thereby maximizing its potential for clinical use. The gene discussed is IDH2; the disease is central nervous system cancer.