In conclusion, our findings expand the current scarce but promising evidence on the diagnostic ability of DKI to predict IDH mutational status, and by employing texture analysis and SVM on the DKI maps we rendered a small selection of biomarkers to distinguish satisfactorily IDH-mutant from IDH-wild-type tumors as well as grade II from grade III gliomas. This evidence concerns the gene IDH2 and glioma.