For example, in a different mouse model of SCD, a short course of the corticosteroid dexamethasone was shown to inhibit the nuclear factor kappa B (NF-ĸB), a pro-inflammatory transcription factor, and to decrease the expression of the vascular cell adhesion molecule-1 (VCAM-1) and the intercellular adhesion molecule-1 (ICAM-1) in lungs, liver, and skin34. Here, VCAM1 is linked to Schnyder corneal dystrophy.