CD8A and neoplasm: It is notable that all archetypes are highly significant with respect to the enrichment of marker genes among their top-ranked residual genes, with the exception of CD4 T-cell and tumor subclass A. After further examination, we observed that the majority of T-cell markers provided in the paper are for CD8 T-cell and provided tumor markers in this dataset are for MITF over-expressed melanoma tumors.