We then looked at both known, characterized virulence-related genes associated with oral microbiota (collagenase, gingipain, and hemagglutinin) (16) and generalized virulence-related gene products known to promote bacterial colonization and survival in the oral cavity and to exacerbate periodontal disease (nonspecific peptidases or proteases and stress response proteins). This evidence concerns the gene LAP3 and periodontal disorder.