Mice deficient in TLR4 demonstrate HF diet-induced weight gain but are protected against inflammation, hepatic steatosis and insulin resistance (Shi et al. 2006, Poggi et al. 2007, Suganami et al. 2007, Tsukumo et al. 2007, Davis et al. 2008, Spruss et al. 2009, Pierre et al. 2013, Jia et al. 2014, Ferreira et al. 2015). Here, TLR4 is linked to hydrops fetalis.