PTEN and neoplasm: Like BRCA2- and CHEK2-associated tumours, ATM-associated tumours are mostly luminal tumours [42–44] but they do not show a particular histological subtype as observed in BRCA1- (medullary) [45], BRCA2- (lobular) [45], CDH1- (lobular) [46], and PTEN-associated tumours (apocrine) [47].