Furthermore, SCH-527123 has been proven to be capable of suppressing CXCR2-mediated signal transduction through decreased phosphorylation of the NF-kB/mitogen-activated protein kinase (MAPK)/AKT pathway, which leads to decreased cell migration and invasion and increased apoptosis in colorectal cancer cell lines [56]. This evidence concerns the gene NFKB1 and colorectal cancer.