CXCL5 and nasopharyngeal carcinoma: As shown in Fig. 4a, the NPC cells that expressed high levels of only one of the proteins or neither protein presented with the typical cobblestone-like appearance of normal epithelium, whereas the S18-shc and S26-CXCR2-CXCL5 cells with high CXCL5/CXCR2 expression levels both took on spindle-like, fibroblastic morphologies.