The CXCL5/CXCR2 signalling pathway plays a promoting role in some common human malignancies [18–20, 25, 29, 42], but the exact roles of the CXCL5/CXCR2 axis in NPC cell migration and invasion, as well as the underlying mechanisms, remain unclear. The gene discussed is CXCL5; the disease is nasopharyngeal carcinoma.