The primary objective of IDEAL-2 is to examine the effect of calcitriol + ACEI or ARB therapy on urine albumin to creatinine ratio (ACR; measured in a standard clinical biochemistry laboratory) compared to ACEI or ARB therapy alone, after 26 weeks, in individuals with type 2 diabetes (T2DM). The gene discussed is ALB; the disease is type 2 diabetes mellitus.