The S100A12 protein is a ligand for the pattern recognition receptor RAGE (receptor for advanced glycation end products) and activates the nuclear factor kappa B (NF-kB) pathway [6, 14], a mechanism linked to the pathogenesis of autoimmune disorders such as inflammatory bowel disease (IBD) in humans [6, 15, 16]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.