Examples include: Rbm20 (encoding for RNA-binding protein 20) whose mutations in exon 9 of the gene have been linked to familial dilated cardiomyopathy and associated with young age at diagnosis, end-stage heart failure, and high mortality [47, 48]; and MEFV (pyrin encoding gene) whose mutations are a risk factor for early coronary artery disease [49] and are associated with childhood polyarteritis nodosa [50] and vascular complications in Behçet’s disease [51]. This evidence concerns the gene MEFV and polyarteritis nodosa.