As expected, biological pathways, such as acute phase response, interleukin-6, iNOS, and atherosclerosis signaling, and functions, such as activation of vascular endothelial cells, atherogenesis, hypercholesterolemia and transport of lipid, were predicted to be deregulated in CVD based on the observed protein changes. This evidence concerns the gene NOS2 and familial hypercholesterolemia.