Jamar et al. [28] found that plasminogen activator inhibitor 1 (PAI1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that may increase the risk related to obesity, and NC was shown to be an independent predictor of PAI1 after adjustment for sex and BMI. The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.