SHANK2 and neuroblastoma: Human neuroblastoma cells (SH-SY5Y) were transfected with a dual luciferase reporter plasmid (psiCHECKTM-2) containing either the wild type (wt) SHANK2 3′UTR sequence or a miR-137 binding site-mutated 3′UTR (mut) together with either miR-137 or negative control miRNA mimics (Fig. 1a).