In the present study, we set out to determine the effect of dietary MOS supplementation on systemic inflammation and plasma lipid levels in the progression of atherosclerosis, using female hyperlipidemic ApoE*3‐Leiden.CETP (E3L.CETP) mice, a well‐established mouse model for hyperlipidemia and atherosclerosis development.23, 24. The gene discussed is CETP; the disease is atherosclerosis.