Adiponectin is an insulin‐sensitizing adipocytokine that preserves hepatic insulin sensitivity via a number of mechanisms including increased AMP‐activated protein kinase phosphorylation and reduced expression of gluconeogenic enzymes.42, 43 HMW adiponectin is a greater predictor of T2D risk than total adiponectin,8 potentially attributable to increased binding affinity to adiponectin receptors.44 While several RCTs have examined the impact of LC n‐3 PUFA on adiponectin,21, 45 few studies have examined the effect of anti‐inflammatory nutritional combinations. The gene discussed is INS; the disease is type 2 diabetes mellitus.