INS and obesity due to melanocortin 4 receptor deficiency: Adiponectin mediates its insulin‐sensitizing effects via its receptors ADIPOR1 and ADIPOR2, the expression of which are downregulated in obesity.48 Using PBMC as a surrogate for adipose tissue,34 the AINS increased ADIPOR1 and ADIPOR2 mRNA expression relative to placebo treatment.