Furthermore, silencing of Pin 1 didn't affect the cell cycle and induce obvious apoptosis by itself in BV173 cells, which was shown in the Figure 2E and F. However, when Pin 1 silencing was combined with the BCR‐ABL inhibitor imatinib, we observed a significantly higher increase in the apoptosis levels with respect to Con‐shRNA BV173 or Con‐siRNA NALM‐1 cells (Fig. 2F–H), revealing that Pin 1 depletion increased the sensitivity of imatinib treatment in ph+ ALL. Here, BCR is linked to acute lymphoblastic leukemia.