TSC2 and B-cell chronic lymphocytic leukemia: To determine whether PIM inhibition interferes with mTOR pathway, we first incubated CLL cells with SEL24‐B489 and found decreased phosphorylation of mTOR pathway components, including p‐mTOR (S2448), p‐TSC2 (S1798) and p‐AKT (S473; Figure 5B).