To determine whether PIM inhibition interferes with mTOR pathway, we first incubated CLL cells with SEL24‐B489 and found decreased phosphorylation of mTOR pathway components, including p‐mTOR (S2448), p‐TSC2 (S1798) and p‐AKT (S473; Figure 5B). The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.