NFKB1 and B-cell chronic lymphocytic leukemia: Chronic lymphocytic leukaemia cell fate depends on microenvironment signals, which promote anti‐apoptotic and proliferative circuitry involving STAT and NFκB transcription factors.6, 7 Since these transcription factors are known PIM inducers,23 we hypothesized that expression of PIM kinases might be regulated by the interaction between CLL cells and their microenvironment.