Activation of CXCR4 induces CLL cells chemotaxis, transendothelial migration and exhibits direct anti‐apoptotic effects.8, 9, 10, 11 Given the role of CXCR4 in CLL cell motility and viability, mechanisms regulating CXCR4 activity and CXCR4‐triggered signal transduction are particularly interesting as potential therapeutic targets. This evidence concerns the gene CXCR4 and B-cell chronic lymphocytic leukemia.