Consistent with this, primary CLL cells isolated from lymph nodes exhibit gene expression signatures characterized by activation of the B‐cell receptor (BCR) pathway, NFκB pathway and increased expression of E2F target genes.5 Trafficking of neoplastic B cells to these proliferation‐conducive compartments is controlled by chemokines.6, 7 One of the key chemokines involved in CLL cells homing is CXCL12 (formerly stromal‐cell derived factor 1, SDF1). This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.