EGFR is a client protein of HSP90 and highly expressed in the majority of ESCC cells.12 EGFR signaling through PI3K‐AKT and MAPK‐ERK to exert its oncogene function.13 In KYSE140 and KYSE180 cells, PU‐H71, a kind of HSP90 inhibitor, induced a decrease of EGFR protein level. This evidence concerns the gene AKT1 and esophageal squamous cell carcinoma.