Therefore, impact of genotypes of CCL-2 (both promoter, the coefficient of rs1024611 is significant, as well as exonic SNP variants) and CCR-2 genes on reference genotypes may lead to the predictive modeling which may support the experimental evidence of enhanced expression of CCL-2 in AMD patients as compared to controls, and/or may also modify the binding affinity of CCL-2 ligand with its receptor (CCR-2). Here, CCR2 is linked to age-related macular degeneration.