Interesting finding from Pham et al have demonstrated allelic variance at rs1024611 which leads to allelic expression imbalance (AIE) of CCL2 which has been reported in various disease phenotypes including atherosclerosis, tuberculosis suggesting that the given allele expression is context dependent which could be influenced with interaction of various proteins [13] that is consistent with our previous findings [4]. The gene discussed is CCL2; the disease is tuberculosis.