The term T‐cell memory “inflation” was first used 15 years ago to describe a phenomenon seen after infection of inbred mouse strains with murine cytomegalovirus.1 It is a striking phenomenon that was made quite evident by the use of MHC‐peptide tetramers to track responses in the infected animals over time.2, 3, 4 The term is now in reasonably common use5, 6 and the actual features of the responses induced which can be called “inflationary” are quite robustly reproducible between different laboratories using different virus stocks, mouse lines, and infection protocols. Here, HLA-C is linked to infection.