Studies using the same approach of longitudinal tracking by MHC‐peptide tetramers based on some of the previously described epitopes in the BALB/c system revealed similar profiles to the immune response, although since these were endogenous epitopes with a clear track record of detection (ie, relatively immunodominant), the populations were also observed during the early phases of infection.1, 3 Nevertheless, the apparent “memory” responses to some epitopes did not show classical contraction and indeed the phenomenon of late expansion was also seen. Here, HLA-C is linked to infection.