DNA methylation and acetylation of histones are two major epigenetic regulation mechanisms in miR‐1‐3p and miR‐206 expression; meanwhile, many nuclear transcription factors, such as NRF2,17 nuclear receptor subfamily 0, group B member 2, oestrogen‐related receptor γ, yin‐yang 1, and activator protein 1, were reported involved in miR‐206 regulation.34, 35 In this study, we showed that HGF induced a decrease in miR‐1‐3p/miR‐206 expression in both PC‐9 and HCC‐827 cells. The gene discussed is HGF; the disease is hepatocellular carcinoma.