Furthermore, protein data (IHC and RPPA) confirmed the observations made at mRNA level for the key genes CTNNB1, CD274 (PDL-1), and LCK. The strength of this recapitulation is significant, as the LMC is made up of primary tumors while the TCGA melanoma data set is predominantly composed of metastases. Here, CTNNB1 is linked to melanoma.