Overall, approximately 32% of the reduced risk of HF seen for elevated magnesium appeared to be explained by AF, IL-6, vWF and cardiac markers (NT-proBNP, cTnT) combined (Model 6) after adjustment for the established risk factors [(0.56–0.70)/(0.56–1)*100]. The gene discussed is NPPB; the disease is atrial fibrillation.