In the present study we aimed to identify molecular prognostic markers for grade II IDH mutated astrocytoma (in particular loss of 10q, trisomy of chromosome 7, PTEN mutations) and in grade II IDH mutated 1p19q-codeleted oligodendroglioma (in particular loss of 9p21.3, CIC, FUBP1, and PTEN mutations). This evidence concerns the gene CIC and oligodendroglioma.