APP and early-onset autosomal dominant Alzheimer disease: Numerous animal models, such as drug-treated rodents (e.g., STZ-treated rats) and various transgenic animals (e.g., APP (swe)/PS1(e9d)1 transgenic mouse strain, Tg2576 mouse model) [39, 40], have been developed to parallel the pathogenesis of human Alzheimer's disease in ways that allow their use in creation of novel preventive and therapeutic strategies.