Numerous animal models, such as drug-treated rodents (e.g., STZ-treated rats) and various transgenic animals (e.g., APP (swe)/PS1(e9d)1 transgenic mouse strain, Tg2576 mouse model) [39, 40], have been developed to parallel the pathogenesis of human Alzheimer's disease in ways that allow their use in creation of novel preventive and therapeutic strategies. Here, APP is linked to Alzheimer disease.