It has been demonstrated that IL-6 drives the progression toward the acquisition of a malignant phenotype of cancer cells (15) and that the blockade of IL-6 signaling has strong effects in vivo on tumor progression, interfering broadly with tumor-supportive stromal functions, including angiogenesis, fibroblast infiltration, and myeloid suppressor cell recruitment in both the tumor and premetastatic niche (117). This evidence concerns the gene IL6 and cancer.