The systemic inflammation present in a psoriasis patient has been shown to yield hyperhomocysteinemia, elevated highly sensitive-C-reactive protein (hs-CRP), platelet hyperactivity, and elevated blood inflammatory cytokines (e.g., IL-6, TNF-a, IL- 23, IL-17, IL-20, IL-22), all of which may also contribute to the increased incidence of ischemic heart disease [27]. The gene discussed is CRP; the disease is psoriasis.